[Recovery of neuromuscular block after continuous infusion of cisatracurium in patients with renal dysfunction]. / Récupération du bloc neuromusculaire après perfusion continue de cisatracurium chez l'insuffisant rénal.
Ann Fr Anesth Reanim
; 20(5): 446-51, 2001 May.
Article
in Fr
| MEDLINE
| ID: mdl-11419239
ABSTRACT
OBJECTIVE:
Study of the recovery of neuromuscular block after continuous infusion of cisatracurium in patients with renal dysfunction. STUDYDESIGN:
Prospective case-control study. PATIENTS Forty adult patients scheduled for urological surgery were assigned to two groups according to the creatinine clearance (CC) as a measure of the renal function group IR (CC < 60 mL.min-1) or group NR (CC > or = 60 mL.min-1).METHODS:
After premedication with hydroxyzine, anaesthesia was induced with propofol, sufentanil and cisatracurium (0.15 mg.kg-1), and maintained using isoflurane, sufentanil and a continuous infusion of cisatracurium (0.12 mg.kg-1.h-1) adjusted for maintained a post-tetanic count < or = 5. Neuromuscular transmission was monitored at the adductor pollicis using accelerography (TOF Gard). Onset and recovery times in both groups were compared using Student's t test.RESULTS:
Infusion time and total dose of cisatracurium were comparable in both groups. Onset times were 3.9 +/- 0.8 min and 3.5 +/- 0.6 min in groups IR and NR respectively. After the infusion, the time to train-of-four ratio of 0.8 were not different in both groups 77 +/- 18 min (group IR) and 73 +/- 13 min (group NR). However, the spontaneous recovery intervals 25%-75% were delayed in group IR (20 +/- 9 min vs 14 +/- 5 min p < 0.05).CONCLUSION:
There are minor differences in the pharmacodynamics of cisatracurium between patients with normal or impaired renal function. Nevertheless, a marked interindividual variability in the recovery parameters was observed in patients with renal dysfunction.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Atracurium
/
Neuromuscular Blockade
/
Kidney Diseases
/
Neuromuscular Blocking Agents
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
Fr
Journal:
Ann Fr Anesth Reanim
Year:
2001
Document type:
Article
Affiliation country:
Francia