Cyclic AMP-Dependent Protein Kinases/metabolism; Gonadal Steroid Hormones/metabolism; Isoenzymes/metabolism; Nitric Oxide Synthase/metabolism; Pain/metabolism; Protein Kinase C/metabolism; Signal Transduction/physiology; Adrenergic Agonists/pharmacology; Animals; Central Nervous System/drug effects; Central Nervous System/metabolism; Central Nervous System/physiopathology; Cyclic AMP-Dependent Protein Kinases/drug effects; Dinoprostone/pharmacology; Enzyme Inhibitors/pharmacology; Estradiol/pharmacology; Female; Inflammation/chemically induced; Inflammation/metabolism; Inflammation/physiopathology; Intercellular Signaling Peptides and Proteins; Isoenzymes/drug effects; Isoenzymes/genetics; MAP Kinase Kinase 1; Male; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase Kinases/drug effects; Mitogen-Activated Protein Kinase Kinases/metabolism; Neurons/drug effects; Neurons/metabolism; Nitric Oxide Synthase/drug effects; Pain/chemically induced; Pain/physiopathology; Peptides/pharmacology; Protein Kinase C/drug effects; Protein Kinase C/genetics; Protein Kinase C-epsilon; Protein Serine-Threonine Kinases/drug effects; Protein Serine-Threonine Kinases/metabolism; Rats; Rats, Sprague-Dawley; Sex Characteristics; Signal Transduction/drug effects; omega-N-Methylarginine/pharmacology