Anti-inflammatory effects of 17beta-estradiol pretreatment in men after coronary artery surgery.
J Cardiothorac Vasc Anesth
; 15(4): 455-9, 2001 Aug.
Article
in En
| MEDLINE
| ID: mdl-11505349
ABSTRACT
OBJECTIVE:
To investigate the anti-inflammatory and hemodynamic effects of 17beta-estradiol in men undergoing elective coronary artery bypass graft surgery (CABG).DESIGN:
Prospective, randomized, controlled.SETTING:
Operating room and intensive care unit in a university hospital.PARTICIPANTS:
Twenty-one men undergoing primary, elective CABG surgery. INTERVENTION 17beta-estradiol, 2mg, was given orally twice in 14 hours before the operation. MEASUREMENTS AND MAINRESULTS:
Leukocyte counts, plasma myeloperoxidase, tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, and IL-10 were measured perioperatively. Leukocyte counts were lower in the 17beta-estradiol group than in controls at 6 hours (11.4 +/- 2.0 hours v 15.5 +/- 4.7 hours x 10(9)/L) and 20 hours (11.6 +/- 1.9 hours v 13.6 +/- 2.5 hours x 10(9)/L) after reperfusion (p = 0.03). The release of myeloperoxidase was lower in the 17beta-estradiol group than in controls (5 minutes; 634.4 +/- 213.1 microg/mL v 773.1 +/- 209.3 microg/mL; 4 hours, 305.0 +/- 108.0 microg/mL v 441.3 +/- 191.6 microg/mL; p = 0.02). Systemic vascular resistance index was lower just after cardiopulmonary bypass, and cardiac index was higher postoperatively in the 17beta-estradiol group as compared with controls.CONCLUSION:
Pretreatment with 17beta-estradiol can limit leukocyte activation in men after CABG surgery.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Premedication
/
Coronary Artery Bypass
/
Cytokines
/
Estradiol
/
Anti-Inflammatory Agents
Type of study:
Clinical_trials
/
Observational_studies
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Cardiothorac Vasc Anesth
Journal subject:
ANESTESIOLOGIA
/
CARDIOLOGIA
Year:
2001
Document type:
Article
Affiliation country:
Finlandia