1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).

Heerding, D A; Chan, G; DeWolf, W E; Fosberry, A P; Janson, C A; Jaworski, D D; McManus, E; Miller, W H; Moore, T D; Payne, D J; Qiu, X; Rittenhouse, S F; Slater-Radosti, C; Smith, W; Takata, D T; Vaidya, K S; Yuan, C C; Huffman, W F

Heerding, D A; Chan, G; DeWolf, W E; Fosberry, A P; Janson, C A; Jaworski, D D; McManus, E; Miller, W H; Moore, T D; Payne, D J; Qiu, X; Rittenhouse, S F; Slater-Radosti, C; Smith, W; Takata, D T; Vaidya, K S; Yuan, C C; Huffman, W F.

Affiliation

Heerding DA; GlaxoSmithKline Pharmaceuticals, Antibacterials and Host Defense, 1250 S. Collegeville Road, Collegeville, PA 19426, USA. dirk_a_heerding@sbphrd.com

Bioorg Med Chem Lett ; 11(16): 2061-5, 2001 Aug 20.

Article in En | MEDLINE | ID: mdl-11514139

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Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases / Imidazoles / Anti-Bacterial Agents Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2001 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido

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