The somatomedin hypothesis revisited in a transgenic model.
Growth Horm IGF Res
; 11 Suppl A: S49-52, 2001 Jun.
Article
in En
| MEDLINE
| ID: mdl-11527088
ABSTRACT
Studies of insulin-like growth factor I (IGF-I) gene knockout mice models have clearly shown that IGF-I is necessary for prenatal as well as postnatal body growth in mice. Clinical studies of a patient with an IGF-I gene defect which caused complete absence of IGF-I, verified that it is important for intrauterine and postnatal growth. Recent studies of mice with liver-specific and inducible IGF-I gene knockout indicated that liver-derived IGF-I is not necessary for postnatal body growth, although serum IGF-I levels are decreased by more than 80% in these mice. Therefore, extrahepatic IGF-I is sufficient for maintenance of postnatal body growth in mice. Further investigations are needed to assess whether liver-derived circulating IGF-I is essential for other biological functions.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Body Weight
/
Somatomedins
/
Mice, Transgenic
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Growth Horm IGF Res
Journal subject:
ENDOCRINOLOGIA
Year:
2001
Document type:
Article
Affiliation country:
Suecia
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM