The stereoselective targeting of a specific enzyme-substrate complex is the molecular mechanism for the synergic inhibition of HIV-1 reverse transcriptase by (R)-(-)-PPO464: a novel generation of nonnucleoside inhibitors.

Maga, G; Ramunno, A; Nacci, V; Locatelli, G A; Spadari, S; Fiorini, I; Baldanti, F; Paolucci, S; Zavattoni, M; Bergamini, A; Galletti, B; Muck, S; Hubscher, U; Giorgi, G; Guiso, G; Caccia, S; Campiani, G

Maga, G; Ramunno, A; Nacci, V; Locatelli, G A; Spadari, S; Fiorini, I; Baldanti, F; Paolucci, S; Zavattoni, M; Bergamini, A; Galletti, B; Muck, S; Hubscher, U; Giorgi, G; Guiso, G; Caccia, S; Campiani, G.

Affiliation

Maga G; Istituto di Genetica Biochimica ed Evoluzionistica IGBE-CNR, Pavia 27100, Italy.

J Biol Chem ; 276(48): 44653-62, 2001 Nov 30.

Article in En | MEDLINE | ID: mdl-11572864

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Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Azepines / Reverse Transcriptase Inhibitors / HIV Reverse Transcriptase Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Biol Chem Year: 2001 Document type: Article Affiliation country: Italia Country of publication: Estados Unidos

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