Compliance with cotrimoxazole prophylaxis for the prevention of opportunistic infections in HIV-positive tuberculosis patients in Thyolo district, Malawi.
Int J Tuberc Lung Dis
; 5(9): 843-6, 2001 Sep.
Article
in En
| MEDLINE
| ID: mdl-11573896
ABSTRACT
OBJECTIVE:
To verify compliance with cotrimoxazole prophylaxis in human immunodeficiency virus (HIV) infected tuberculosis (TB) patients during the continuation phase of anti-tuberculosis treatment, and to assess the sensitivity, specificity and positive predictive values of verbal verification and pill counts as methods of checking compliance.DESIGN:
Cross-sectional study.METHODS:
Cotrimoxazole compliance was assessed in a cohort of TB patients who were attending four TB follow-up centres during the continuation phase of anti-TB treatment between months 4 and 6. Verbal verification of drug intake, physical verification of pill count balance, and urine trimethoprim detection by gas chromatography and mass spectrometry were used for assessing compliance.RESULTS:
Using urine trimethoprim detection as the gold standard for compliance, trimethoprim was detected in 82 (94%) of 87 patients in the cohort. Verbal verification of cotrimoxazole intake and objective pill count balances showed high sensitivity and positive predictive values compared with the gold standard of urine trimethoprim detection.CONCLUSIONS:
In a rural district in Malawi, compliance with cotrimoxazole as an adjunct to anti-tuberculosis treatment in HIV-infected TB patients was good, and can be assessed simply and practically by verbal verification and pill counts.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tuberculosis
/
Trimethoprim, Sulfamethoxazole Drug Combination
/
Patient Compliance
/
AIDS-Related Opportunistic Infections
/
Anti-Infective Agents
/
Antitubercular Agents
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Africa
Language:
En
Journal:
Int J Tuberc Lung Dis
Year:
2001
Document type:
Article
Affiliation country:
Malawi