Cytopathic effects of non-syncytium-inducing and syncytium-inducing human immunodeficiency virus type 1 variants on different CD4(+)-T-cell subsets are determined only by coreceptor expression.
J Virol
; 75(21): 10455-9, 2001 Nov.
Article
in En
| MEDLINE
| ID: mdl-11581413
ABSTRACT
In peripheral blood mononuclear cells, syncytium-inducing (SI) human immunodeficiency virus type 1 (HIV-1) infected and depleted all CD4(+) T cells, including naive T cells. Non-SI HIV-1 infected and depleted only the CCR5-expressing T-cell subset. This may explain the accelerated CD4 cell loss after SI conversion in vivo.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
CD4-Positive T-Lymphocytes
/
T-Lymphocyte Subsets
/
HIV-1
/
Receptors, CCR5
/
Receptors, CXCR4
Limits:
Humans
Language:
En
Journal:
J Virol
Year:
2001
Document type:
Article
Affiliation country:
Países Bajos