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[The synthesis and pharmacological activities of C-galactosides of furanosequiterpenes].
Chen, H M; Wang, Y Y; Mao, J M; Cai, M S; Jia, Z J.
Affiliation
  • Chen HM; School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083
Yao Xue Xue Bao ; 32(10): 750-4, 1997 Oct.
Article in Zh | MEDLINE | ID: mdl-11596217
Four new C-galactosides were obtained by treatment of 1-O-trifluoroacetly-2, 3, 4, 6-tetra-O-benzly-alpha-D-galactopranose with 7-methoxy-6-(3-pentenyl)-3, 5-dimethylbenzofuran, 7-acetoxy-6-(3-pentenyl)-3, 5-dimethylbenzofuran and 1, 2-dihydrocacalohastin in the presence of Lewis acid. Their structures and compositions were elucidated by elemental analysis and spectroscopic methods. The results of the pharmacological test indicated that the sesquiterpenes are calcium antagonist but their C-galactosides are calcium agonist.
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Sesquiterpenes / Calcium Channel Blockers / Calcium / Monosaccharides Language: Zh Journal: Yao Xue Xue Bao Year: 1997 Document type: Article Country of publication: China
Search on Google
Collection: 01-internacional Database: MEDLINE Main subject: Sesquiterpenes / Calcium Channel Blockers / Calcium / Monosaccharides Language: Zh Journal: Yao Xue Xue Bao Year: 1997 Document type: Article Country of publication: China