Comparative study of platelet activation markers in diabetes mellitus patients complicated by cerebrovascular disease.
Blood Coagul Fibrinolysis
; 12(7): 531-7, 2001 Oct.
Article
in En
| MEDLINE
| ID: mdl-11685040
ABSTRACT
Cerebrovascular disease and other vascular diseases are common complications of non-insulin-dependent diabetes mellitus (NIDDM) and are associated with its increased morbidity and mortality. Platelet activation plays an important role in the pathomechanisms of these vascular diseases. Although several indices have been used to assess platelet activation, few data are available indicating which are more sensitive or more valuable in this situation. We have measured platelet arachidonic acid metabolites [thromboxane B2 (TXB2) and 11-dehydro-thromboxane B2 (TXB2)] and plasma P-selectin, platelet fibrinogen binding and membrane glycoproteins in 47 well-characterized NIDDM patients with cerebrovascular disease, 38 NIDDM patients without vascular diseases, and 36 age-matched healthy individuals. Our study shows that platelets were remarkably activated in NIDDM patients with cerebrovascular diseases. The measurement of plasma 11-dehydro-TXB2 and the determination of fibrinogen binding to, and P-selectin expression on platelets would reveal a higher diagnostic sensitivity for detecting in vivo platelet activation than other markers.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thromboxane B2
/
Biomarkers
/
Platelet Activation
/
Cerebrovascular Disorders
/
Diabetes Mellitus, Type 2
Limits:
Adult
/
Aged
/
Humans
/
Middle aged
Language:
En
Journal:
Blood Coagul Fibrinolysis
Journal subject:
ANGIOLOGIA
/
HEMATOLOGIA
Year:
2001
Document type:
Article
Affiliation country:
China