Pregnancy outcome and prognosis in fetuses with increased first-trimester nuchal translucency.
Fetal Diagn Ther
; 16(6): 360-3, 2001.
Article
in En
| MEDLINE
| ID: mdl-11694739
ABSTRACT
OBJECTIVE:
One of the concerns of prenatal diagnosis is to find sensitive markers to screen for chromosome abnormalities, such as serum assays or nuchal translucency (NT). This study reports our experience with NT measurement during the first trimester of pregnancy. MATERIALS The study was performed prospectively on 252 fetuses with either NT > or =3 mm or cystic hygroma.RESULTS:
We observed 50 abnormal karyotypes, i.e. 19.8%. The incidence of chromosome abnormalities increased with increasing maternal age and increasing NT thickness. For the 202 fetuses with normal karyotypes, outcome was unfavourable in 32 cases 23 elective terminations of pregnancy, 8 spontaneous abortions and 1 neonatal death. Outcome was favourable in 141 cases. Twenty-nine pregnancies were lost to follow-up.CONCLUSION:
Measurement of NT at 12 weeks' gestation seems to be a good marker for chromosome abnormalities. When the karyotype is normal, the pregnancy outcome remains correlated with the degree of NT thickness. The finding of NT >3 mm between 10 and 14 weeks' gestation dictates rigorous ultrasound monitoring and caution when predicting pregnancy outcome.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy Outcome
/
Ultrasonography, Prenatal
/
Gestational Age
/
Neck
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Fetal Diagn Ther
Journal subject:
DIAGNOSTICO POR IMAGEM
/
OBSTETRICIA
/
PERINATOLOGIA
Year:
2001
Document type:
Article
Affiliation country:
Francia