Effect of tenascin-X together with vascular endothelial growth factor A on cell proliferation in cultured embryonic hearts.
Biol Pharm Bull
; 24(11): 1320-3, 2001 Nov.
Article
in En
| MEDLINE
| ID: mdl-11725972
ABSTRACT
Tenascin-X (TNX) is a large glycoprotein that appears in extracellular matrices. Previously, we demonstrated that TNX binds to vascular endothelial growth factors A and B (VEGF-A and -B) and that VEGF-B in combination with TNX induces DNA synthesis in endothelial cells via increased signals mediated by the VEGFR-1 receptor. In this study, we investigated the effect of TNX with VEGF-A on the cell proliferation in embryonic mouse heart explants from either wild-type (TNX+/+) or TNX-deficient (TNX-/-) mice. The addition of VEGF-A to the explants from TNX+/+ mice increased cell proliferation by 1.5 fold compared with that in TNX-/- mice, indicating that TNX with VEGF family member plays an important role in the control of endothelial cell proliferation in vivo.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Endothelial Growth Factors
/
Tenascin
/
Endocardium
Limits:
Animals
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Biol Pharm Bull
Journal subject:
BIOQUIMICA
/
FARMACOLOGIA
Year:
2001
Document type:
Article
Affiliation country:
Japón