Efficacy of macrolides used in combination with ethambutol, with or without other drugs, against Mycobacterium avium within human macrophages.
Int J Antimicrob Agents
; 18(6): 525-30, 2001 Dec.
Article
in En
| MEDLINE
| ID: mdl-11738339
ABSTRACT
The activities of clarithromycin or roxithromicin used in combination with other antimicrobial drugs were tested in human macrophages experimentally infected with 23 strains of Mycobacterium avium. Overall, clarithromycin-ethambutol-rifampicin was the most active combination tested. The reduction in intracellular viable bacilli was found to be more than 1 log(10) for 95% and more than 2 logs(10) for 65% of the strains. The second most active combination was roxithromycin-ethambutol-rifampicin, which was found to be bactericidal for about 80% and highly bactericidal for 20% of the strains. Others combinations were only bacteriostatic or weakly bactericidal for many of the strains. The addition of a third drug did not necessarily promote enhanced bacterial killing inside the macrophage.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Therapy, Combination
/
Ethambutol
/
Macrophages
/
Anti-Bacterial Agents
/
Mycobacterium avium
/
Antitubercular Agents
Limits:
Humans
Language:
En
Journal:
Int J Antimicrob Agents
Year:
2001
Document type:
Article
Affiliation country:
Italia
Publication country:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS