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Role of hypothalamic neuropeptide Y (NPY) in the change of feeding behavior induced by repeated treatment of amphetamine.
Kuo, D Y; Hsu, C T; Cheng, J T.
Affiliation
  • Kuo DY; Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan, ROC.
Life Sci ; 70(3): 243-51, 2001 Dec 07.
Article in En | MEDLINE | ID: mdl-12005258
ABSTRACT
Neuropeptide Y (NPY), an orexigenic peptide, is involved in the control of food intake. Repeated administration of amphetamine (AMPH), an anorectic agent, results in an anorectic effect on day 1 and a tolerant anorectic effect on the followings. In an attempt to know the role of hypothalamic NPY in these effects of AMPH, contents of hypothalamic NPY were determined by radioimmunoassay at first. In AMPH-treated groups, the contents of hypothalamic NPY decreased rapidly on day 1 but restored gradually to the normal level on the following days as observed in repeated AMPH. An involvement of hypothalamic NPY in the feeding change of repeated AMPH can thus be considered. Moreover, daily injection of NPY antisense oligonucleotide into brain (10 microg/10 microl/day, i.c.v.) to inhibit the gene expression of hypothalamic NPY were performed at 1 hour before daily 2 mg/kg AMPH. The reversion of food intake from the anorectic level to the normal level (tolerant anorexia) was abolished by this antisense pretreatment. It is suggested that hypothalamic NPY may play a role in the change of feeding behavior induced by repeated AMPH administration.
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Neuropeptide Y / Feeding Behavior / Amphetamine / Hypothalamus Limits: Animals Language: En Journal: Life Sci Year: 2001 Document type: Article
Search on Google
Collection: 01-internacional Database: MEDLINE Main subject: Neuropeptide Y / Feeding Behavior / Amphetamine / Hypothalamus Limits: Animals Language: En Journal: Life Sci Year: 2001 Document type: Article
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