Antilymphoproliferative activity of ethanolic extract of Boerhaavia diffusa roots.
Exp Mol Pathol
; 72(3): 236-42, 2002 Jun.
Article
in En
| MEDLINE
| ID: mdl-12009788
ABSTRACT
Extracts of plants have been widely evaluated for possible antiproliferative and anticarcinogenic properties. The antiproliferative activity of ethanolic extract of Boerhaavia diffusa, a plant used in traditional medicine, was evaluated in several cells. It inhibited T cell mitogen phytohemagglutinin and concanavalin A-stimulated proliferation of human peripheral blood mononuclear cells (PBMC). It also inhibited purified protein derivative antigen-stimulated PBMC proliferation and human mixed lymphocyte culture. In addition, B. diffusa extract inhibited the growth of several cell lines of mouse and human origin, such as mouse macrophage cells (RAW 264.7), human macrophage cells (U937), human monocytic cells (THP-1), mouse fibroblast cells (L929), human embryonic kidney cells (HEK293), mouse liver cells (BNLCL.2), African green monkey kidney cells (COS-1), mouse lymphoma cells (EL-4), human erythroleukemic cells (K562), and human T cells (Jurkat). The present study has demonstrated the antiproliferative potential of ethanolic extract of B. diffusa in vitro.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Division
/
Magnoliopsida
Limits:
Animals
/
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Exp Mol Pathol
Year:
2002
Document type:
Article
Affiliation country:
India
Publication country:
HOLANDA
/
HOLLAND
/
NETHERLANDS
/
NL
/
PAISES BAJOS
/
THE NETHERLANDS