[Alterations of rheological properties of blood in systemic sclerodermia]. / Narusheniia reologicheskikh svoistv krovi pri sistemnoi sklerodermii.
Ter Arkh
; 74(5): 43-7, 2002.
Article
in Ru
| MEDLINE
| ID: mdl-12087905
ABSTRACT
AIM:
To study hemorheological status in systemic sclerosis (SS) patients. MATERIAL ANDMETHODS:
Macro- and microrheology of blood were investigated in 70 SS patients. The rate of spontaneous aggregation of red blood cells [T1(s)], durability of the largest units [Ia2.5(%)], general hydrodynamic durability of units [beta(s-1)], limit of fluidity [tau 0 (mPa)], Casson viscosity K (mPa/s) were determined.RESULTS:
The total severity of hemorheological disturbances was 1.90 +/- 0.07 with T1 = 4.98 +/- 1.52s, beta = 62.76 +/- 19.32s, Ia 2.5 = -0.78 +/- 12.83%, tau 0 = 7.00 +/- 0.45 mPa. The Casson viscosity did not differ from normal levels. Plasma viscosity was 1.71 +/- 0.18 rel units, viscosity of sera 1.55 +/- 0.14 rel.units. The severity of hemorheological disturbances did not differ in cute and chronic courses but the parameter beta (72.0 +/- 4.5) was significantly higher (p < 0.05) in the acute course. The severity of hemorheological disturbances was highest in SS patients with cardiac disease (p < 0.05) and in 10 year SS duration.CONCLUSION:
The course of SS is complicated by progressive hyperaggregation syndrome promoting development of visceral pathology. Active correction of hemorheology is pathogenetically validated in SS.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Scleroderma, Systemic
Type of study:
Diagnostic_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
Ru
Journal:
Ter Arkh
Year:
2002
Document type:
Article