Role of Wnt pathway in medulloblastoma oncogenesis.
Int J Cancer
; 101(2): 198-201, 2002 Sep 10.
Article
in En
| MEDLINE
| ID: mdl-12209999
ABSTRACT
To clarify the roles of Wnt pathway in medulloblastoma oncogenesis, immunohistochemical staining of beta-catenin and Wnt-1 and genomic analyses of CTNNB1 (beta-catenin) and AXIN1 (axin 1) were examined in 23 sporadic cases. Accumulation of beta-catenin in tumor cells was immunohistochemically proven in 5 cases; 2 cases showed positive immunoreactivity for Wnt-1 and another 2 showed mutation of either CTNNB1 or AXIN1. AXIN1 mutation was in exon 3, corresponding to GSK-3beta binding site and CTNNB1 mutation was in exon 3, corresponding to its phosphorylation site. Disruption of these proteins could result in upregulation of the Wnt signaling and accumulation of beta-catenin, followed by cell proliferation and medulloblastoma oncogenesis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Repressor Proteins
/
Signal Transduction
/
Proteins
/
Trans-Activators
/
Proto-Oncogene Proteins
/
Cytoskeletal Proteins
/
Zebrafish Proteins
/
Medulloblastoma
Limits:
Humans
Language:
En
Journal:
Int J Cancer
Year:
2002
Document type:
Article
Affiliation country:
Japón