Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine.

Filla, Sandra A; Winter, Mark A; Johnson, Kirk W; Bleakman, David; Bell, Michael G; Bleisch, Thomas J; Castaño, Ana M; Clemens-Smith, Amy; del Prado, Miriam; Dieckman, Donna K; Dominguez, Esteban; Escribano, Ana; Ho, Ken H; Hudziak, Kevin J; Katofiasc, Mary A; Martinez-Perez, Jose A; Mateo, Ana; Mathes, Brian M; Mattiuz, Edward L; Ogden, Ann Marie L; Phebus, Lee A; Stack, Douglas R; Stratford, Robert E; Ornstein, Paul L

Filla, Sandra A; Winter, Mark A; Johnson, Kirk W; Bleakman, David; Bell, Michael G; Bleisch, Thomas J; Castaño, Ana M; Clemens-Smith, Amy; del Prado, Miriam; Dieckman, Donna K; Dominguez, Esteban; Escribano, Ana; Ho, Ken H; Hudziak, Kevin J; Katofiasc, Mary A; Martinez-Perez, Jose A; Mateo, Ana; Mathes, Brian M; Mattiuz, Edward L; Ogden, Ann Marie L; Phebus, Lee A; Stack, Douglas R; Stratford, Robert E; Ornstein, Paul L.

Affiliation

Filla SA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, 46285, USA. filla_sandra_a@lilly.com

J Med Chem ; 45(20): 4383-6, 2002 Sep 26.

Article in En | MEDLINE | ID: mdl-12238915

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Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Carboxylic Acids / Receptors, Kainic Acid / Excitatory Amino Acid Antagonists / Esters / Isoquinolines / Migraine Disorders Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2002 Document type: Article Affiliation country: Estados Unidos

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