Therapy-related acute myeloblastic leukemia after mitoxantrone treatment in a patient with MS.
Neurology
; 59(6): 954-5, 2002 Sep 24.
Article
in En
| MEDLINE
| ID: mdl-12297591
ABSTRACT
The authors report a patient with severe secondary progressive MS who responded to mitoxantrone but developed a fatal acute myeloblastic leukemia 15 months after completion of mitoxantrone therapy. Therapy-related acute leukemia (TRAL) in relation with mitoxantrone is rare; this patient was the first case among a cohort of 802 French MS patients treated with mitoxantrone. Nevertheless, this case stresses the need to further evaluate the long-term risk of TRAL in patients with MS who receive mitoxantrone.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leukemia, Myeloid, Acute
/
Mitoxantrone
/
Multiple Sclerosis
Type of study:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
Neurology
Year:
2002
Document type:
Article
Affiliation country:
Francia