The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase.

Brown, Murray J; Carter, Paul S; Fenwick, Ashley S; Fosberry, Andrew P; Hamprecht, Dieter W; Hibbs, Martin J; Jarvest, Richard L; Mensah, Lucy; Milner, Peter H; O'Hanlon, Peter J; Pope, Andrew J; Richardson, Christine M; West, Andrew; Witty, David R

Brown, Murray J; Carter, Paul S; Fenwick, Ashley S; Fosberry, Andrew P; Hamprecht, Dieter W; Hibbs, Martin J; Jarvest, Richard L; Mensah, Lucy; Milner, Peter H; O'Hanlon, Peter J; Pope, Andrew J; Richardson, Christine M; West, Andrew; Witty, David R.

Affiliation

Brown MJ; GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK.

Bioorg Med Chem Lett ; 12(21): 3171-4, 2002 Nov 04.

Article in En | MEDLINE | ID: mdl-12372526

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Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcus aureus / Tryptophan-tRNA Ligase / Enzyme Inhibitors / Indoles / Anti-Bacterial Agents Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2002 Document type: Article Affiliation country: Reino Unido

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