Thymidine 3',5'-diphosphoric acid derived cations and radicals: ab initio study.

ABSTRACT

The relative stabilities of thymidine-3',5'-diphosphoric acid (1) derived isomeric cations and radicals were calculated and key geometric parameters were thoroughly analyzed. The most probable sites of a hydride-ion (1', 2', 5-Me) and H-atom (4', 5', 5-Me) abstraction were identified, thus allowing prediction of the regioselectivity of potential damage to the deoxyribose ring and thymine moiety caused by carcinogenic agents of electrophilic and radical nature. [structure see text]