The complex relationship between soluble and insoluble tau in tauopathies revealed by efficient dephosphorylation and specific antibodies.
FEBS Lett
; 531(3): 538-42, 2002 Nov 20.
Article
in En
| MEDLINE
| ID: mdl-12435607
Phosphorylated tau is deposited as insoluble inclusion bodies in the tauopathies. We have used a new efficient method to dephosphorylate tau extracted from control and tauopathy brain. In some tauopathies, including Alzheimer's disease and progressive supranuclear palsy, the pattern of insoluble tau isoforms reflected that of soluble tau. In contrast, in corticobasal degeneration, Pick's disease, and some forms of fronto-temporal dementia, specific tau isoforms were selectively sequestered into insoluble inclusion-forming tau. Therefore the overall expression of individual tau isoforms does not predict which tau isoforms are deposited in all tauopathies and different mechanisms must operate that result in the deposition of specific tau isoforms.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Diseases
/
Tau Proteins
/
Protein Isoforms
Limits:
Humans
Language:
En
Journal:
FEBS Lett
Year:
2002
Document type:
Article
Country of publication:
Reino Unido