Activation of cell-survival signal Akt by GDNF in normal rat brain.
Brain Res
; 958(2): 429-33, 2002 Dec 27.
Article
in En
| MEDLINE
| ID: mdl-12470880
ABSTRACT
Glial cell line-derived neurotrophic factor (GDNF) activates protein kinase Akt/PKB by phosphorylation (p-Akt) which plays key roles in cell survival. In the current study, we investigated a temporal expression of p-Akt by immunohistochemical analysis after a topical application of GDNF to normal cerebral hemisphere of rats. Although p-Akt immunoreactivity was weakly present in the sham control neural cells, GDNF application greatly enhanced it at 3 h, which lasted until 1 day. These results indicate that p-Akt is expressed in neuronal cells under physiological conditions, and that topical application of GDNF greatly enhanced the phosphorylation of Akt in normal rat brain.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Signal Transduction
/
Proto-Oncogene Proteins
/
Protein Serine-Threonine Kinases
/
Nerve Growth Factors
Limits:
Animals
Language:
En
Journal:
Brain Res
Year:
2002
Document type:
Article
Affiliation country:
Japón