Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore.
Bioorg Med Chem Lett
; 13(12): 2075-8, 2003 Jun 16.
Article
in En
| MEDLINE
| ID: mdl-12781198
ABSTRACT
A series of 1,2-dihydrochromeno[3,4-f]quinoline derivatives was synthesized and tested in biological assays to evaluate the nonsteroidal progesterone receptor modulator pharmacophore (4) as antiprogestins. A number of potent analogues were identified by modification of the substituents at the D-ring.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quinolines
/
Receptors, Progesterone
Limits:
Animals
/
Humans
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2003
Document type:
Article
Affiliation country:
Estados Unidos