Comparative analysis of the PLUNC (palate, lung and nasal epithelium clone) protein families.
Biochem Soc Trans
; 31(Pt 4): 806-9, 2003 Aug.
Article
in En
| MEDLINE
| ID: mdl-12887310
ABSTRACT
PLUNC (palate, lung and nasal epithelium clone) is a small, secreted protein that is expressed in the oropharynx and upper airways of humans, mice and rats. We have described a family of at least 14 PLUNC genes localized on chromosome 20 (in humans), 2 (in mice) or 3 (in rats). These rapidly evolving proteins are structurally related to lipopolysaccharide-binding protein (LBP) and bactericidal/permeability-increasing protein (BPI). In the present analysis we comment on the comparative aspects of this protein family, which may function to protect epithelial surfaces from pathogenic micro-organisms.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phosphoproteins
/
Glycoproteins
Limits:
Animals
/
Humans
Language:
En
Journal:
Biochem Soc Trans
Year:
2003
Document type:
Article
Affiliation country:
Reino Unido