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A validated 1H NMR method for the determination of the degree of deacetylation of chitosan.
Lavertu, M; Xia, Z; Serreqi, A N; Berrada, M; Rodrigues, A; Wang, D; Buschmann, M D; Gupta, Ajay.
Affiliation
  • Lavertu M; Department of Chemical Engineering, Institute of Biomedical and Chemical Engineering, Ecole Polytechnique of Montréal, PO Box 6079, Station Center-Ville, Québec, Montréal, Canada.
J Pharm Biomed Anal ; 32(6): 1149-58, 2003 Aug 21.
Article in En | MEDLINE | ID: mdl-12907258
ABSTRACT
A method for the determination of the degree of deacetylation (DDA) of chitosan by 1H NMR spectroscopy has been formally validated. Chitosans with DDA ranging from 48 to 100% have been used for the validation. The method is found to be simple, rapid and more precise than other known techniques like IR or titration for %DDA measurements. The precision, ruggedness, robustness, specificity, stability and accuracy of the technique are discussed in this paper.
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Collection: 01-internacional Database: MEDLINE Main subject: Magnetic Resonance Spectroscopy / Chitin Language: En Journal: J Pharm Biomed Anal Year: 2003 Document type: Article Affiliation country: Canadá
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Collection: 01-internacional Database: MEDLINE Main subject: Magnetic Resonance Spectroscopy / Chitin Language: En Journal: J Pharm Biomed Anal Year: 2003 Document type: Article Affiliation country: Canadá