Cellular metabolism of (-) enantiomeric 2'-deoxy-3'-thiacytidine.
Biochem Pharmacol
; 43(10): 2059-64, 1992 May 28.
Article
in En
| MEDLINE
| ID: mdl-1318048
ABSTRACT
The metabolism of (-) enantiomeric 2'-deoxy-3'-thiacytidine (3TC) was examined in human immunodeficiency virus type 1 (HIV-1)-infected and mock-infected human cells. 3TC 5'-triphosphate levels accumulated comparably in HIV-1-infected and mock-infected phytohaemagglutinin-stimulated peripheral blood lymphocytes (PBL) and reached 40% or more of total intracellular 3TC metabolites after 4 hr. The rate of decay of 3TC triphosphate in HIV-1-infected and mock-infected PBL measured as a half-life (T1/2) ranged from 10.5 to 15.5 hr. 3TC did not significantly affect metabolism of deoxynucleotides in the U937 cell line, and was shown to be resistant to the action of human platelet pyrimidine nucleoside phosphorylase.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thymidine Phosphorylase
/
Blood Platelets
/
Zalcitabine
Limits:
Humans
Language:
En
Journal:
Biochem Pharmacol
Year:
1992
Document type:
Article
Affiliation country:
Reino Unido