In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism. | Arch Biochem Biophys;294(2): 454-60, 1992 May 01. | MEDLINE

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In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism.

Vincent, S H; Karanam, B V; Painter, S K; Chiu, S H.

Affiliation

Vincent SH; Department of Animal and Exploratory Drug Metabolism, Merck Sharp & Dohme Research Laboratories, New Jersey 07065.

Arch Biochem Biophys ; 294(2): 454-60, 1992 May 01.

Article in En | MEDLINE | ID: mdl-1373595

Subject(s)

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Collection: 01-internacional Database: MEDLINE Main subject: Microsomes, Liver / Tacrolimus / Cytochrome P-450 Enzyme System / Mixed Function Oxygenases Type of study: Diagnostic_studies Limits: Adult / Animals / Female / Humans / Male Language: En Journal: Arch Biochem Biophys Year: 1992 Document type: Article Country of publication: Estados Unidos

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Collection: 01-internacional Database: MEDLINE Main subject: Microsomes, Liver / Tacrolimus / Cytochrome P-450 Enzyme System / Mixed Function Oxygenases Type of study: Diagnostic_studies Limits: Adult / Animals / Female / Humans / Male Language: En Journal: Arch Biochem Biophys Year: 1992 Document type: Article Country of publication: Estados Unidos