Hemodynamic effects of carvedilol after acute oral administration in hypertensive and normal subjects.
J Cardiovasc Pharmacol
; 19 Suppl 1: S35-9, 1992.
Article
in En
| MEDLINE
| ID: mdl-1378147
ABSTRACT
Forearm hemodynamics using pulsed Doppler flowmetry were studied in nine healthy volunteers and 12 patients with mild-to-moderate hypertension before and after acute oral administration of the beta-blocking and vasodilating agent carvedilol. Both the 25- and the 50-mg dose produced a significant blood pressure reduction by comparison with placebo in normotensive and hypertensive subjects. Only the 50-mg dose caused a decrease in forearm vascular resistance in hypertensive subjects. The decrease disappeared after wrist occlusion. Although brachial artery diameter did not change, a significant decrease in tangential tension was observed. This study provides evidence that carvedilol produced arteriolar dilation within the forearm of hypertensive subjects in association with a decrease in brachial artery tangential tension.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Propanolamines
/
Carbazoles
/
Adrenergic beta-Antagonists
/
Hemodynamics
/
Hypertension
/
Antihypertensive Agents
Type of study:
Clinical_trials
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Cardiovasc Pharmacol
Year:
1992
Document type:
Article
Affiliation country:
Francia