Immunocytological confirmation of bone marrow metastases in a dog with cholangiocarcinoma.
J Small Anim Pract
; 44(9): 411-4, 2003 Sep.
Article
in En
| MEDLINE
| ID: mdl-14510332
ABSTRACT
The case history of a four-year-old, male Bernese mountain dog is presented. Carcinoma cells were detected in the liver by ultrasound-guided fine-needle aspiration. Bone marrow aspirated from the iliac crest and the left femur showed a distinct infiltration by carcinoma cells. Immunocytological examination of the liver and bone marrow metastases showed a negative staining result for large spectrum cytokeratin (CK) KL1, a strong positive result for CK7 and a focal weak positive result for CK20. The dog was euthanased due to the grave prognosis. Histopathological examination revealed metastatic cholangiocarcinoma. The authors conclude that cytological and immunocytological examination of bone marrow aspirates should be used more frequently for the detection of distant metastases of carcinomas in small animal medicine.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cholangiocarcinoma
/
Bone Marrow Neoplasms
/
Dog Diseases
/
Liver Neoplasms
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
J Small Anim Pract
Year:
2003
Document type:
Article
Affiliation country:
Alemania