Action of GABA-B antagonist on cortical epileptic afterdischarges in rats is similar to that of GABA-A antagonist.
Physiol Res
; 52(5): 651-5, 2003.
Article
in En
| MEDLINE
| ID: mdl-14535842
ABSTRACT
Threshold intensities for epileptic phenomena induced by cortical stimulation were used for comparison of the action of GABA-B and GABA-A antagonists in rats with implanted electrodes. Both CGP 35348 (200 mg/kg i.p.) and bicuculline (4 mg/kg i.p.) significantly decreased thresholds for spike-and-wave afterdischarges and their motor counterpart (clonic seizures) whilst transition into the second, limbic type of afterdischarge as well as threshold for movements directly bound to stimulation remained uninfluenced by either drug.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cerebral Cortex
/
GABA Antagonists
/
Epilepsy
/
GABA-A Receptor Antagonists
/
GABA-B Receptor Antagonists
Limits:
Animals
Language:
En
Journal:
Physiol Res
Journal subject:
FISIOLOGIA
Year:
2003
Document type:
Article
Affiliation country:
República Checa