Amine oxidases and tumors.
Neurotoxicology
; 25(1-2): 317-24, 2004 Jan.
Article
in En
| MEDLINE
| ID: mdl-14697906
ABSTRACT
The physiological function in living organisms of amine oxidases, is not completely established but is certainly related to the biogenic amines metabolism and therefore involved in essential processes such as the cell growth and differentiation. A correlation between degree of tumor malignancy and level of AO activity has been reported. The catalytic products of oxidative deamination of amines (hydrogen peroxide and aminoaldehyde) exert a cytotoxic effect and are considered cell growth inhibitors. The biogenic amines in same way could be considered in the cells as both poisons and protectors. A balance of oxidant and antioxidant enzymes appears to be very important in carcinogenesis and cell growth regulation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Amine Oxidase (Copper-Containing)
/
Monoamine Oxidase
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Neurotoxicology
Year:
2004
Document type:
Article
Affiliation country:
Italia