Adequacy of early empiric antibiotic treatment and survival in severe sepsis: experience from the MONARCS trial.
Clin Infect Dis
; 38(2): 284-8, 2004 Jan 15.
Article
in En
| MEDLINE
| ID: mdl-14699463
ABSTRACT
As part of the Monoclonal Anti-TNF A Randomized Controlled Sepsis (MONARCS) trial, which enrolled patients with suspected sepsis, we sought to determine whether adequate antibiotic therapy was associated with a decreased mortality rate. The study enrolled 2634 patients, 91% of whom received adequate antibiotic therapy. The mortality rate among patients given adequate antibiotic treatment was 33%, versus 43% among patients given inadequate treatment (P<.001). We conclude that adequate antibiotic therapy results in a significant decrease in the crude mortality rate among patients suspected of sepsis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sepsis
/
Anti-Bacterial Agents
Type of study:
Clinical_trials
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Clin Infect Dis
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2004
Document type:
Article
Affiliation country:
Estados Unidos