Upregulation of cardiac ghrelin mRNA in leptin-deficient and leptin receptor-deficient mice with viral myocarditis.
J Int Med Res
; 31(6): 503-8, 2003.
Article
in En
| MEDLINE
| ID: mdl-14708415
ABSTRACT
Expression of cardiac and gastric ghrelin messenger (m) RNA, together with heart and body weights, were measured in leptin-deficient (ob) and leptin receptor-deficient (db) mice with heart failure induced by viral myocarditis. Significant elevations in cardiac ghrelin mRNA levels and heart weight were observed in ob and db mice 10 days after viral inoculation compared with baseline values. Expression of gastric ghrelin mRNA was not upregulated in ob and db mice on day 10. The elevated expression of cardiac ghrelin mRNA seems to compensate for the lack of upregulation in gastric ghrelin mRNA.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Virus Diseases
/
Receptors, Cell Surface
/
Leptin
/
Peptide Hormones
/
Myocarditis
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
J Int Med Res
Year:
2003
Document type:
Article
Affiliation country:
Japón