Chorioamnionitis increases matrix metalloproteinase-8 concentrations in bronchoalveolar lavage fluid from preterm babies.
Arch Dis Child Fetal Neonatal Ed
; 89(1): F61-4, 2004 Jan.
Article
in En
| MEDLINE
| ID: mdl-14711859
ABSTRACT
OBJECTIVE:
To determine the effects of chorioamnionitis and antenatal corticosteroids on matrix metalloproteinase-8 (MMP-8) concentrations in bronchoalveolar lavage (BAL) fluid from preterm babies in the first week of life.DESIGN:
Prospective observational study.SETTING:
Regional neonatal intensive care unit. PATIENTS Thirty five ventilated preterm babies < 33 weeks gestation, seven of whom were born after chorioamnionitis, which was diagnosed histologically as the presence of inflammatory cells in the chorioamnionic plate.METHODS:
MMP-8 was measured by enzyme linked immunosorbent assay (ELISA) in 90 serial BAL samples taken during the first six postnatal days. The median MMP-8 concentration for each baby was calculated.RESULTS:
Median MMP-8 concentrations were higher in the chorioamnionitis group than in those without (43 v 5 ng/ml). Partial or complete courses of antenatal corticosteroids had no effect on MMP-8 concentrations.CONCLUSIONS:
Higher concentrations of MMP-8 are found in BAL fluid from preterm babies from pregnancies complicated by chorioamnionitis. This type I collagenase may contribute to the lung injury that occurs in some babies with respiratory distress syndrome.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Infant, Premature
/
Bronchoalveolar Lavage Fluid
/
Chorioamnionitis
/
Adrenal Cortex Hormones
/
Matrix Metalloproteinase 8
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
Language:
En
Journal:
Arch Dis Child Fetal Neonatal Ed
Journal subject:
PEDIATRIA
/
PERINATOLOGIA
Year:
2004
Document type:
Article