[Metabolic changes in salivary glands with concurrent stomach ulcer and their correction by L-arginine]. / Metabolichni zminy v slynnykh zalozakh za peptychnoï virazky shlunka ta ïkh korektsiia L-arhininom.

ABSTRACT

On the model of peptic ulcer the mechanisms of interrelations between salivary glands and stomach have been proved. Activation of proteolysis which took place together with a decrease in the activity of alpha 1--inhibitor for proteases in lipid peroxidation (LPO), and an increase in depolymerization of glycoproteins contributed much to that pathology. The most pronounced metabolic changes in the tissues of the salivary glands were observed in stress resistant animals. The preliminary administration of NO donor L-arginin prevented an activation of proteolysis and LPO intensity. It attenuated the pathogenic influence of the factors which induced the metabolic changes in salivary glands at peptic ulcer of the stomach.