Association of homozygous wild-type glutathione S-transferase M1 genotype with increased breast cancer risk.
Cancer Res
; 64(4): 1233-6, 2004 Feb 15.
Article
in En
| MEDLINE
| ID: mdl-14973116
ABSTRACT
More than 500 studies have examined the association of the glutathione S-transferase M1 (GSTM1) genotype with various malignancies yielding inconsistent results. The genotyping was based on a PCR assay that identified the GSTM1 null (-/-) genotype but did not distinguish homozygous wild-type (+/+) and heterozygous (+/-) individuals. We developed an assay that allowed the definition of +/+, +/-, and -/- genotypes by separate identification of wild-type and null alleles, which were found with frequencies of 0.225 and 0.775, respectively, in Caucasian women. We applied the new assay to a breast cancer case-control study and identified the +/+ genotype in 14 (6.9%) of 202 control subjects compared with 37 (18.2%) of 203 patients. Compared with women with the -/- genotype, the relative risk of breast cancer for the +/+ genotype was 2.83 (95% confidence interval, 1.45-5.59; P = 0.002), suggesting a protective effect of the GSTM1 deletion.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Glutathione Transferase
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Cancer Res
Year:
2004
Document type:
Article
Affiliation country:
Estados Unidos