Synthesis of novel 2,3-dihydro-1,4-dioxino[2,3-g]quinoline derivatives as potential antitumor agents.
Bioorg Med Chem
; 12(5): 949-56, 2004 Mar 01.
Article
in En
| MEDLINE
| ID: mdl-14980607
ABSTRACT
New dioxinoquinolines (1-8) have been synthesized and their antiproliferative properties have been tested against several cell lines. The treatment of the 6-acetamido-2,3-dihydro-1,4-benzodioxine (10) with phosphorous oxychloride in the presence of DMF leads to a mixture of linear and angular tricyclic compounds. The key intermediates were modified and cyclized giving the corresponding dioxinoquinolines. In general, these compounds have a moderate citotoxycity.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quinolines
/
Antineoplastic Agents
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Bioorg Med Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2004
Document type:
Article
Affiliation country:
España