N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.

Misra, Raj N; Xiao, Hai-yun; Kim, Kyoung S; Lu, Songfeng; Han, Wen-Ching; Barbosa, Stephanie A; Hunt, John T; Rawlins, David B; Shan, Weifang; Ahmed, Syed Z; Qian, Ligang; Chen, Bang-Chi; Zhao, Rulin; Bednarz, Mark S; Kellar, Kristen A; Mulheron, Janet G; Batorsky, Roberta; Roongta, Urvashi; Kamath, Amrita; Marathe, Punit; Ranadive, Sunanda A; Sack, John S; Tokarski, John S; Pavletich, Nikola P; Lee, Francis Y F; Webster, Kevin R; Kimball, S David

Misra, Raj N; Xiao, Hai-yun; Kim, Kyoung S; Lu, Songfeng; Han, Wen-Ching; Barbosa, Stephanie A; Hunt, John T; Rawlins, David B; Shan, Weifang; Ahmed, Syed Z; Qian, Ligang; Chen, Bang-Chi; Zhao, Rulin; Bednarz, Mark S; Kellar, Kristen A; Mulheron, Janet G; Batorsky, Roberta; Roongta, Urvashi; Kamath, Amrita; Marathe, Punit; Ranadive, Sunanda A; Sack, John S; Tokarski, John S; Pavletich, Nikola P; Lee, Francis Y F; Webster, Kevin R; Kimball, S David.

Affiliation

Misra RN; Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 4000, Princeton, New Jersey 08543-4000, USA. raj_n_misra@hotmail.com

J Med Chem ; 47(7): 1719-28, 2004 Mar 25.

Article in En | MEDLINE | ID: mdl-15027863

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Collection: 01-internacional Database: MEDLINE Main subject: Oxazoles / Thiazoles / CDC2-CDC28 Kinases / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2004 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos

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