Tissue angiotensin-converting enzyme in imposed and physiological flow-related arterial remodeling in mice.
Arterioscler Thromb Vasc Biol
; 24(5): 892-7, 2004 May.
Article
in En
| MEDLINE
| ID: mdl-15031129
ABSTRACT
OBJECTIVE:
To test whether membrane-bound angiotensin I-converting enzyme (t-ACE) is involved in arterial remodeling, we applied unilateral carotid artery (CA) ligation and studied uterine arteries (UA) before, during, and after pregnancy in t-ACE-/- and t-ACE+/+ mice. RESULTS- In CA of t-ACE-/- mice, blood pressure, outer diameter (D), and medial cross-sectional area (mCSA) were reduced, whereas blood flow (BF) and the number of medial cells (mC) were not modified. In the ligated CA, mCSA and number of mC were increased while outer D and distensibility were reduced. These changes were significantly less pronounced in t-ACE-/- than t-ACE+/+ mice. In UA of t-ACE-/- mice, D was larger and mCSA was unaltered. At term pregnancy, D and mCSA of the UA were reversibly increased. Structural changes of UA during and after pregnancy were comparable in both strains.CONCLUSIONS:
t-ACE contributes to arterial structure and remodeling. It plays a major role in hyperplastic inward remodeling of the CA imposed by blood flow cessation, but it is not essential for outward hypertrophic and subsequent inward hypotrophic remodeling of the UA during and after pregnancy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Uterus
/
Carotid Arteries
/
Hemorheology
/
Peptidyl-Dipeptidase A
/
Membrane Proteins
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
Arterioscler Thromb Vasc Biol
Journal subject:
ANGIOLOGIA
Year:
2004
Document type:
Article
Affiliation country:
Países Bajos