Synthesis and evaluation of gastroprotective and antiulcer activity of some 2-substituted-1H-imidazo[4,5-b] pyridines and -1H-benzimidazoles.
Farmaco
; 47(3): 287-303, 1992 Mar.
Article
in En
| MEDLINE
| ID: mdl-1503593
ABSTRACT
Several compounds possessing imidazo[4,5-b]pyridine and benzimidazole structure bearing substituents in position 2 were prepared in order to evaluate an anti-ulcer and gastroprotective activity in rat pylorus ligature, in comparison with omeprazole. Among sixteen compounds taken as representatives of the synthetised series only one (3d) showed a good activity by i.m. administration at 50 mg/kg, while by oral administration of 100 mg/kg a certain number was active and in some cases this activity was quite superior to that of omeprazole.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyridines
/
Stomach
/
Benzimidazoles
/
Imidazoles
/
Anti-Ulcer Agents
Limits:
Animals
Language:
En
Journal:
Farmaco
Journal subject:
FARMACOLOGIA
/
QUIMICA
Year:
1992
Document type:
Article