The effect of valsartan on regression of left ventricular hypertrophy in type 2 diabetic patients.
Diabetes Obes Metab
; 6(3): 195-9, 2004 May.
Article
in En
| MEDLINE
| ID: mdl-15056127
ABSTRACT
AIM:
The aim of the present study was to examine the effects of an angiotensin II receptor antagonist, valsartan, on echocardiographically proven left ventricular hypertrophy (LVH) in patients with type 2 diabetes.METHODS:
Outpatients with type 2 diabetes mellitus were recruited at Niigata University Hospital. The left ventricular mass index (LVMI) was calculated by echocardiography. LVH was considered to be present if the LVMI was > 131 g/m(2) in males and > 100 g/m(2) in females. Patients with LVH received a low dose (40 mg/day) of valsartan for 12 months. This low dose had no clinical effect on blood pressure.RESULTS:
Of the 38 patients who entered the study, 14 (36.8%) had LVH. After only 6 months of valsartan therapy, the mean LVMI decreased significantly, from 126.5 +/- 27.8 to 119.0 +/- 23.5 g/m(2) (p < 0.01 vs. baseline). Also, a significant decrease was observed after 12 months (116.5 +/- 30.9 g/m(2), p < 0.05 vs. baseline). Compared to baseline, there were no significant differences after treatment in body mass index, glycosylated haemoglobin (HbA(1c)), systolic blood pressure and diastolic blood pressure.CONCLUSIONS:
In type 2 diabetic patients with LVH, treatment with a low dose of valsartan, an angiotensin II receptor antagonist, for 12 months, reduced LVMI, with no reduction in systemic blood pressure. This drug may be safely administered to type 2 diabetic patients with LVH. The long-term risk-reduction effects will have to be evaluated in further trials.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tetrazoles
/
Valine
/
Hypertrophy, Left Ventricular
/
Angiotensin II Type 1 Receptor Blockers
/
Diabetes Mellitus, Type 2
/
Diabetic Angiopathies
/
Antihypertensive Agents
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Diabetes Obes Metab
Journal subject:
ENDOCRINOLOGIA
/
METABOLISMO
Year:
2004
Document type:
Article
Affiliation country:
Japón