Clinical pharmacokinetics of alpha 1-antitrypsin in homozygous PiZ deficient patients.
Clin Pharmacokinet
; 23(2): 161-8, 1992 Aug.
Article
in En
| MEDLINE
| ID: mdl-1511530
ABSTRACT
A pharmacokinetic study of alpha 1-antitrypsin (ATT) was performed in 2 groups of homozygous PiZ-deficient patients (treated and untreated) and 1 group of healthy volunteers. The distribution of the 131I-labelled protein corresponds to a 3-compartment model. The intravenously administered protein diffused quickly to the extravascular compartment where some retention occurred. No significant difference in AAT metabolism was observed between the 3 groups. The half-life of the injected protein is slightly longer than 2.5 days. The AAT protein was not stored. These results confirm the observations collected during the clinical trials. That is, a weekly infusion is necessary to obtain stable serum AAT concentrations. Monthly infusions are unable to maintain a 'plateau' phase. The periodicity may be limited to every 2 weeks.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Alpha 1-Antitrypsin
/
Alpha 1-Antitrypsin Deficiency
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Clin Pharmacokinet
Year:
1992
Document type:
Article
Affiliation country:
Francia