[Serological surveillance on vaccine against hemorrhagic fever with renal syndrome].
Zhonghua Liu Xing Bing Xue Za Zhi
; 25(5): 400-2, 2004 May.
Article
in Zh
| MEDLINE
| ID: mdl-15231163
ABSTRACT
OBJECTIVE:
To observe the serological and epidemiological efficacy of hemorrhagic fever renal syndrome (HFRS) vaccine in Zhejiang province.METHODS:
Immunofluorescent antibody assay and Mcro-CPE method were used to test specific IgG antibody and the titer of neutralizing antibody.RESULTS:
Two weeks after the injection of the third dose, the sero-conversion rates by both immunofluorescent antibody test (IgG) and neutralization test were 100.0% (67/67) (95% CI 96.3 - 100.0) and 44.4% (8/18)(95% CI 22.0 - 69.0) with geometric mean titers (GMTs) 72.1 and 4.6 respectively. The rates of seroconversion of immunofluorescent antibody by immunofluorescence antibody assay (IFA) were 28.6%, 83.3%, 75.0%, 53.1%, 22.6%, 10.0% and 55.0% before reinforcement, two weeks, one year, one year and a half years, two years, three years and five years after reinforcement. The rates of neutralizing antibody seroconversion by the Mcro-CPE method were found as 14.8%, 55.6%, 35.0%, 31.3%, 26.0%, 10.0% and 50.0% respectively. We found some antibody dependent immunization enhancement phenomenon among the inoculated population, but further observation was needed.CONCLUSION:
HFRS vaccine was immunologically effective and the duration of serous antibody last long.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Viral Vaccines
/
Vaccination
/
Hantaan virus
/
Hemorrhagic Fever with Renal Syndrome
Type of study:
Screening_studies
Limits:
Adolescent
/
Adult
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
Zh
Journal:
Zhonghua Liu Xing Bing Xue Za Zhi
Year:
2004
Document type:
Article
Affiliation country:
China