Synthesis and conformation analysis of 3-substituted derivatives of 1H,3H-pyrido[2,3-d] pyrimidin-4-one of expected depressive nervous system. Part III.
Acta Pol Pharm
; 61(1): 45-54, 2004.
Article
in En
| MEDLINE
| ID: mdl-15259857
ABSTRACT
Four series of new 1-aryl (heteroaryl) piperazinylacetyl derivatives of 1H,3H-pyrido[2,3-d] pyrimidin-4-one VIIa-o were synthesised. Substrates for the synthesis of VIa-d were obtained from the respective 3H-pyrido[2.3-d]pyrimidines IVa-d in the reaction with NaBH4. Compounds VIa-d were prepared by chloroacetylation. The obtained 1-chloroacetyl derivatives in the reaction with respective aryl (heteroaryl) piperazine formed 1-aminoacetyl derivatives of 2-phenyl-1 H.3H-pyrido[2.3-d]pyrimidin-4-one compounds VII1a-n. The structure ol compounds was analysed by 1H, 13C NMR spectroscopy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrimidinones
/
Central Nervous System Depressants
Language:
En
Journal:
Acta Pol Pharm
Year:
2004
Document type:
Article
Affiliation country:
Polonia