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The relationship between aberrant methylation and survival in non-small-cell lung cancers.
Toyooka, S; Suzuki, M; Maruyama, R; Toyooka, K O; Tsukuda, K; Fukuyama, Y; Iizasa, T; Aoe, M; Date, H; Fujisawa, T; Shimizu, N; Gazdar, A F.
Affiliation
  • Toyooka S; Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Br J Cancer ; 91(4): 771-4, 2004 Aug 16.
Article in En | MEDLINE | ID: mdl-15266335
ABSTRACT
The present study examined the relationship between methylation of five genes (p16(INK4a), RASSF1A, APC, RARbeta and CDH13) and patient survival in 351 cases of surgically resected lung cancers. While there was no relationship between the other genes and survival, p16(INK4a) methylation was significantly related to unfavourable prognosis in lung adenocarcinomas.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA, Neoplasm / Adenocarcinoma / Carcinoma, Non-Small-Cell Lung / DNA Methylation / Genes, p16 / Lung Neoplasms Type of study: Observational_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Br J Cancer Year: 2004 Document type: Article Affiliation country: Estados Unidos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA, Neoplasm / Adenocarcinoma / Carcinoma, Non-Small-Cell Lung / DNA Methylation / Genes, p16 / Lung Neoplasms Type of study: Observational_studies Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Br J Cancer Year: 2004 Document type: Article Affiliation country: Estados Unidos