[Corneal anomalies in murine trisomy 16]. / Minoranomalien der Hornhaut bei der murinen Trisomie 16.
Ophthalmologe
; 102(1): 64-9, 2005 Jan.
Article
in De
| MEDLINE
| ID: mdl-15300387
ABSTRACT
BACKGROUND:
The prevalence of human Down's syndrome is about 1700. Investigations using animal models are therefore of clinical relevance for understanding its etiopathogenesis. No corneal changes have been reported with transgenic murine trisomy 16.METHODS:
A total of 20 fetal mice (n=40 eyes) with experimentally induced trisomy 16 were investigated from day 18 of pregnancy in order to determine whether visible developmental disorders of the cornea occur. All specimen were investigated microscopically in serial sections.RESULTS:
In addition to disturbances in systemic development, the transgenic mouse fetuses showed high rates of malformation of the eyes. Developmental and differentiation disorders of the corneal epithelial cell layers and structural disturbances of the corneal parenchyma were found. Our findings are the first demonstration of developmental disorders of the cornea in mouse fetuses with trisomy 16. These minor anomalies of the cornea could well have resulted in keratoconus if the animals had survived.CONCLUSIONS:
Our findings in transgenic mouse fetuses with trisomy 16 correspond to the clinical pattern of Down's syndrome in humans. Disturbed development of lids and lenses have a high prevalence, whereas corneal hypoplasia is found less often.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trisomy
/
Down Syndrome
/
Cornea
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Animals
/
Pregnancy
Language:
De
Journal:
Ophthalmologe
Journal subject:
OFTALMOLOGIA
Year:
2005
Document type:
Article