Drug-induced neurobehavioral plasticity: the role of environmental context.
Behav Pharmacol
; 15(5-6): 327-39, 2004 Sep.
Article
in En
| MEDLINE
| ID: mdl-15343056
ABSTRACT
Repeated administrations of addictive drugs produce long-lasting changes in brain and behavior. However, drug-induced neurobehavioral plasticity is not a mere function of the neuropharmacological actions of drugs, but the result of complex drug-environment interactions. In the present review we summarize results obtained in a series of studies using an animal model of drug-environment interaction, showing that environmental context and past drug history interact to modulate the effects of amphetamine, cocaine and morphine on behavior, gene expression and structural plasticity. These findings may help shed some light on the conditions necessary for addictive drugs to enduringly alter brain and behavior.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Substance-Related Disorders
/
Environment
/
Exploratory Behavior
/
Central Nervous System Stimulants
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Behav Pharmacol
Journal subject:
CIENCIAS DO COMPORTAMENTO
/
FARMACOLOGIA
Year:
2004
Document type:
Article
Affiliation country:
Italia