Entropy; Protozoan Proteins/metabolism; Triose-Phosphate Isomerase/metabolism; Animals; Binding Sites/genetics; Calorimetry; Catalysis; Chickens; Deuterium Exchange Measurement; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/metabolism; Glycine/genetics; Glycine/metabolism; Glycolates/chemistry; Glycolates/metabolism; Kinetics; Leishmania mexicana/enzymology; Leishmania mexicana/genetics; Mutagenesis, Insertional; Nuclear Magnetic Resonance, Biomolecular; Phosphorus Isotopes/metabolism; Protein Conformation; Protozoan Proteins/antagonists & inhibitors; Protozoan Proteins/genetics; Pyruvaldehyde/metabolism; Recombinant Proteins/antagonists & inhibitors; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Triose-Phosphate Isomerase/antagonists & inhibitors; Triose-Phosphate Isomerase/genetics