Attenuation of cocaine-induced conditioned place preference by Polygala tenuifolia root extract.
Life Sci
; 75(23): 2751-64, 2004 Oct 22.
Article
in En
| MEDLINE
| ID: mdl-15464827
ABSTRACT
A recent investigation indicated that Polygala tenuifolia Willdenow extract (PTE) possesses a potential antipsychotic effect. In this study, we examined the effects of PTE on the cocaine-induced changes in locomotor activity, conditioned place preference (CPP), fos-related antigen-immunoreactivity (FRA-IR), and activator protein (AP)-1 DNA binding activity. Cocaine-induced behavioral effects (hyperlocomotion and CPP) occurred in parallel with increases in FRA-IR and AP-1 DNA binding activity in the nucleus accumbens. These responses induced by cocaine were consistently attenuated by concurrent treatment with PTE (25 mg or 50 mg/kg/day, i.p. x 7). The adenosine A2A receptor antagonist, 1,3,7-trimethyl-8-(3-chlorostyrl)xanthine (0.5 or 1.0 mg/kg, i.p.), reversed the PTE-mediated pharmacological action in a dose related manner; neither the adenosine A(1) receptor antagonist, 8-cyclopentyl-1,3-dimethylxanthine (0.5 or 1.0 mg/kg, i.p.) nor the A2B receptor antagonist, alloxazine (1.5 or 3.0 mg/kg, i.p.) significantly affected this pharmacological action. Our results suggest that PTE prevents cocaine-induced behavioral effects, at least in part, via the activation of the adenosine A2A receptor.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spatial Behavior
/
Cocaine
/
Plant Roots
/
Polygala
/
Locomotion
Limits:
Animals
Language:
En
Journal:
Life Sci
Year:
2004
Document type:
Article
Affiliation country:
Corea del Sur